The Prognostic Value of a Tumor Microenvironment-Based Immune Cell Infiltration Score Model in Colon Cancer

Frontiers in Oncology

Xingkui Tang¹  Xijun Luo¹  Minling Liu²  Shan Huang²  Mengyuan Zhu²  Xiaofen Pan² 

[1] Department of General Surgery, Guangzhou Panyu Central Hospital, Guangzhou, China;Department of Oncology, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China;

关键词: colon cancer;    immune cell infiltration;    tumor microenvironment;    prognostic biomarker;    survival;   

DOI  :  10.3389/fonc.2021.728842

来源: DOAJ

【 摘 要 】

The current study aimed to construct a prognostic predictive model based on tumor microenvironment. CIBERSORT and ESTIMATE algorithms were used to reveal the immune cell infiltration (ICI) landscape of colon cancer. Patients were classified into three clusters by ConsensusClusterPlus algorithm. ICI scores of each patient were determined by principal component analysis. Patients were divided into high and low ICI score groups. Survival, gene expression, and somatic mutation of the two groups were compared. We found that patients with no lymph node invasion, no metastasis, T1–2 disease, and stage I–II had higher ICI scores. Calcium signaling pathway, leukocyte transendothelial migration pathway, MAPK signaling pathway, TGF β pathway, and Wnt signaling pathway were enriched in the high ICI score group. Immune-checkpoint and immune-activity associated genes were decreased in high ICI score patients. Patients in the high ICI score group had better survival. Prognostic value of ICI score was independent of tumor mutational burden (TMB). The ICI score model constructed in the current study may serve as an independent prognostic biomarker in colon cancer.

【 授权许可】

Unknown