QTc Prolongation Risk Evaluation in Female COVID-19 Patients Undergoing Chloroquine and Hydroxychloroquine With/Without Azithromycin Treatment

Frontiers in Cardiovascular Medicine

John B. Kostis¹  Marcel P. H. van den Broek²  Martin Cour³  Lior Jankelson⁴  Sarah Grewal⁵  Kamana Misra⁵  Gloria Bachmann⁶ 

[1] Cardiovascular Institute, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, United States;Department of Clinical Pharmacy, St. Antonius Hospital, Utrecht, Netherlands;Hospices Civils de Lyon, Hôpital Edouard Herriot, Service de Médecine—Intensive Réanimation, Lyon, France;NYU Langone Health, New York University School of Medicine, New York, NY, United States;Pharmacovigilance, ContraRx, NJ, United States Edison, NJ, United States;Women's Health Institute, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, United States;

关键词: COVID;    QTc changes;    hydroxychloroquine;    chloroquin;    azithromycin (AZM);    QTc;   

DOI  :  10.3389/fcvm.2020.00152

来源: DOAJ

【 摘 要 】

Women have higher risk for developing TdP in response to ventricular repolarization prolonging drugs. Hundreds of trials are administering chloroquine and hydroxychloroquine with/without azithromycin to COVID-19 patients. While an overall prolonged QTc has been reported in COVID-19 patients undergoing these treatments, the question on even higher QTc elevation risk in thousands of female COVID-19 patients undergoing these treatments remains unanswered. We therefore explore data reported and shared with us to evaluate safety and efficacy of antimalaria pharmacotherapies in female COVID-19 patients. Although we observed longer mean QTc intervals in female patients in 2 of the 3 cohorts reviewed, the sex disproportionality in COVID-19 hospitalizations precludes a clear sex mediated QTc interval elevation risk association in the female COVID-19 patients undergoing acute treatment regimens. Adoption of study designs that include observation of sex mediated differential triggering of cardiac electrical activity by these drugs is warranted.

【 授权许可】

Unknown