Shift work and the incidence of prostate cancer: a 10-year follow-up of a German population-based cohort study

Scandinavian Journal of Work, Environment & Health

Thomas Brüning¹  Nico Dragano¹  Karl-Heinz Jöckel¹  Lewin Eisele¹  Marina Arendt¹  Raimund Erbel¹  Katharina Wichert¹  Sylvia Rabstein¹  Thomas Behrens² 

[1] ;Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Institute of the Ruhr-Universität Bochum (IPA), Bürkle-de-la-Camp-Platz 1, 44789 Bochum, Germany.;

关键词: cancer;    cohort study;    shift work;    prostate cancer;    night work;    germany;    population-based cohort study;    circadian disruption;    chronotype;    vitamin d;    sleep preference;    heinz nixdorf recall study;   

DOI  :  10.5271/sjweh.3666

来源: DOAJ

【 摘 要 】

OBJECTIVES: We investigated the association of shift and night work with the incidence of prostate cancer using data of the population-based prospective Heinz Nixdorf Recall Study from the highly industrialized Ruhr area in Germany. METHODS: Participants of the baseline survey were recruited between 2000–2003. A follow-up survey including, a detailed interview on shift and night work, was conducted from 2011–2014. We included 1757 men who did not report a history of prostate cancer at baseline. We assessed shift- and night-work exposure up to time of the baseline interview. Incident prostate cancers were recorded from baseline through September 2014. We calculated hazard ratios (HR) of shift- and night-work exposure using Cox proportional hazards regression with age at event as timescale, adjusting for smoking status, family history of prostate cancer, education (≤13, 14–17, ≥18 years), and equivalent income (low, medium, high). RESULTS: We observed a twofold increased HR for prostate cancer among shift and night workers. Ever employment in shift work was associated with HR 2.29, 95% confidence interval (CI) 1.43–3.67 and night work with HR 2.27, 95% CI 1.42–3.64. HR increased steadily with duration of employment in shift or night work. Stratifying analyses by preferred midpoint of sleep, yielded strongly elevated HR among subjects with early sleep preference, although these analyses were limited by small number of cases. CONCLUSIONS: We identified increased risks for prostate cancer among men with employment in shift or night work. HR were strongly elevated among long-term employed shift workers and men with early preferred midpoint of sleep.

【 授权许可】

Unknown