Mechanisms Mediating Nuclear Trafficking Involved in Viral Propagation by DNA Viruses

Viruses

Guohui Li¹  Xinyu Qi¹  Zhaoyang Hu¹  Qi Tang¹ 

[1] Institute of Life Sciences, Jiangsu University, Zhenjiang 212013, Jiangsu, China;

关键词: viral propagation;    nlss;    cnlss;    ncnlss;    viral replication;    expression regulation;    virion assembly;   

DOI  :  10.3390/v11111035

来源: DOAJ

【 摘 要 】

Typical viral propagation involves sequential viral entry, uncoating, replication, gene transcription and protein synthesis, and virion assembly and release. Some viral proteins must be transported into host nucleus to facilitate viral propagation, which is essential for the production of mature virions. During the transport process, nuclear localization signals (NLSs) play an important role in guiding target proteins into nucleus through the nuclear pore. To date, some classical nuclear localization signals (cNLSs) and non-classical NLSs (ncNLSs) have been identified in a number of viral proteins. These proteins are involved in viral replication, expression regulation of viral genes and virion assembly. Moreover, other proteins are transported into nucleus with unknown mechanisms. This review highlights our current knowledge about the nuclear trafficking of cellular proteins associated with viral propagation.

【 授权许可】

Unknown