Effect of Single-Dose Methotrexate Treatment on Ovarian Reserve in Women with Ectopic Pregnancy Undergoing Infertility Treatment: A Single-Center Experience

International Journal of Fertility and Sterility

Marjan Ghaemi¹  Parichehr Pooransari²  Fatemeh Davari Tanha²  Zeinab Shaker²  Mahboobeh Shirazi³  Mohadeseh Ghazi³  Batool Ghorbani Yekta³  Neda Hajiha⁴ 

[1] 4Young Researchers and Ethics Club, Tehran Medical Science Branch, Islamic Azad University, Tehran, Iran;Breast Feeding Research Center, Tehran University of Medical Sciences, Tehran, Iran;Maternal, Fetal and Neonatal Research Center, Tehran, Iran;Shohada Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran;

关键词: anti;    mullerian hormone;    assisted reproductive techniques;    ectopic pregnancy;    methotrexate;    ovarian reserve;   

DOI  :  10.22074/ijfs.2020.5938

来源: DOAJ

【 摘 要 】

BackgroundThe aim of this study was evaluation of the impact of single-dose methotrexate (MTX) treatment onovarian reserve in women with ectopic pregnancy (EP) undergoing infertility treatment in Iranian population.Materials and MethodsThis prospective cohort study was done between March 2015 and March 2017 in TehranGeneral Women Hospital, Tehran, Iran. We enrolled 20 patients with EP who conceived during infertility treatmentand received a single-dose MTX (50 mg/m2) intramuscularly. Serum anti-Mullerian hormone (AMH), 17 beta-estra diol(E2), luteinizing hormone (LH), follicle-stimulating hormone (FSH) and antral follicle count (AFC) ontransvaginal ultrasonography, were evaluated before and 8 weeks after administration of MTX.ResultsAMH did not significantly vary after the administration of MTX, compared to before treatment value(P=0.36). FSH, E2 and AFC changes were not statistically significant, while increment of LH was significant (P=0.02).ConclusionResults indicated that single-dose MTX treatment did not reduce ovarian reserve in women with EP.Further randomized controlled clinical trial studies with larger sample sizes, by using multiple dosages of MTX, and withlong-term follow up are suggested to be done.

【 授权许可】

Unknown