Structural disorders of the sperm chromatin. Pathophysiological aspects. Clinical relevance

Vestnik Urologii

D. M. Korshunov¹  P. S. Kyzlasov²  M. N. Korshunov³  E. S. Korshunova³  S. P. Darenkov⁴ 

[1] A.I. Yevdokimov Moscow State University of Medicine and Dentistry;Research Center of Neurology;Central State Medical Academy, The Administrative Directorate of the President of the Russian Federation;State Research Center of the Russian Federation - A. I. Burnazyan Federal Medical Biophysical Center;

关键词: sperm chromatin;    sperm dna fragmentation;    review;    male infertility;    varicocele;    oxidative stress;    reactive oxygen species;    assisted reproductive technique;    pregnancy loss;   

DOI  :  10.21886/2308-6424-2021-9-1-95-104

来源: DOAJ

【 摘 要 】

The review provides an analysis of domestic and foreign sources devoted to the study of the sperm chromatin structure. The pathogenetic pathways of the sperm DNA fragmentation formation are described. The relationship between sperm DNA damage in pregnancy, live birth rate and the recurrent pregnancy losses in the assisted reproductive technique are presented. The prognostic determination's value of the sperm DNA fragmentation in male infertility cases is noted.

【 授权许可】

Unknown