Cellular Basis of Embryonic Hematopoiesis and Its Implications in Prenatal Erythropoiesis

International Journal of Molecular Sciences

Toshiyuki Yamane¹ 

[1]Department of Stem Cell and Developmental Biology, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu 514-8507, Japan

关键词: erythropoiesis;    primitive erythrocyte;    embryonic hematopoiesis;    fetal hematopoiesis;    yolk sac;    fetal liver;   

DOI  :  10.3390/ijms21249346

来源: DOAJ

【 摘 要 】

Primitive erythrocytes are the first hematopoietic cells observed during ontogeny and are produced specifically in the yolk sac. Primitive erythrocytes express distinct hemoglobins compared with adult erythrocytes and circulate in the blood in the nucleated form. Hematopoietic stem cells produce adult-type (so-called definitive) erythrocytes. However, hematopoietic stem cells do not appear until the late embryonic/early fetal stage. Recent studies have shown that diverse types of hematopoietic progenitors are present in the yolk sac as well as primitive erythroblasts. Multipotent hematopoietic progenitors that arose in the yolk sac before hematopoietic stem cells emerged likely fill the gap between primitive erythropoiesis and hematopoietic stem-cell-originated definitive erythropoiesis and hematopoiesis. In this review, we discuss the cellular origin of primitive erythropoiesis in the yolk sac and definitive hematopoiesis in the fetal liver. We also describe mechanisms for developmental switches that occur during embryonic and fetal erythropoiesis and hematopoiesis, particularly focusing on recent studies performed in mice.

【 授权许可】

Unknown