A Case Control Study on Serum Levels of Potential Biomarkers in Male Breast Cancer Patients

International Journal of Environmental Research and Public Health

Yahya Mohzari¹  Mohammed Asad²  KamalEldin Ahmed Abdelsalam²  MonjidAhmed Ibrahim Ahmed²  SyedMohammed Basheeruddin Asdaq³  NajwaJilan Alghamdi⁴  Ahmed Alrashed⁵  KholoudNasser Alrami⁶  WaelAhmed Alharbi⁶ 

[1] Clinical Pharmacy Department, King Saud Medical City, Riyadh 12746, Saudi Arabia;Department of Clinical Laboratory Science, College of Applied Medical Sciences, Shaqra University, Shaqra 11911, Saudi Arabia;Department of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Dariyah, Riyadh 13713, Saudi Arabia;Department of Pharmacy, Adham General Hospital, Adham 28653, Saudi Arabia;Pharmaceutical Services Administration, Inpatient Department, Main Hospital, KFMC, Riyadh 11564, Saudi Arabia;Pharmaceutical Services Department, King Fahad Medical City, Riyadh 11564, Saudi Arabia;

关键词: dopamine;    epinephrine;    GABA;    ghrelin;    melatonin;    serotonin;   

DOI  :  10.3390/ijerph18094852

来源: DOAJ

【 摘 要 】

The global incidence of breast cancer among men is steadily growing. Despite this, compared to female breast cancer patients, there are very few studies on biomarkers in male breast cancer patients. A cross-sectional case control study was carried out to determine the serum levels of melatonin, ghrelin, dopamine, serotonin, epinephrine, and GABA in male breast cancer. All the recruited patients were obese, old, and had recently been diagnosed with the disease. They had not received any treatment for the cancer until the time of the study. Melatonin and epinephrine serum levels were significantly higher in breast cancer patients compared to their age-matched controls, whereas ghrelin, dopamine, GABA, and serotonin serum levels were lower in patients compared to the control group. The serum levels of most of the studied biomarkers in male breast cancer patients were similar to those observed in female breast cancer patients, except for serum melatonin levels.

【 授权许可】

Unknown