Targeting Energy Metabolism in Cancer Treatment

International Journal of Molecular Sciences

Barbara Madej-Czerwonka¹  Joanna Kubik²  Grzegorz Adamczuk²  Ewelina Humeniuk²  Agnieszka Korga-Plewko² 

[1] Human Anatomy Department, Faculty of Medicine, Medical University of Lublin, 20-090 Lublin, Poland;Independent Medical Biology Unit, Faculty of Pharmacy, Medical University of Lublin, 20-093 Lublin, Poland;

关键词: cancer metabolism;    cancer treatment;    glycolysis;    oxidative phosphorylation;   

DOI  :  10.3390/ijms23105572

来源: DOAJ

【 摘 要 】

Cancer is the second most common cause of death worldwide after cardiovascular diseases. The development of molecular and biochemical techniques has expanded the knowledge of changes occurring in specific metabolic pathways of cancer cells. Increased aerobic glycolysis, the promotion of anaplerotic responses, and especially the dependence of cells on glutamine and fatty acid metabolism have become subjects of study. Despite many cancer treatment strategies, many patients with neoplastic diseases cannot be completely cured due to the development of resistance in cancer cells to currently used therapeutic approaches. It is now becoming a priority to develop new treatment strategies that are highly effective and have few side effects. In this review, we present the current knowledge of the enzymes involved in the different steps of glycolysis, the Krebs cycle, and the pentose phosphate pathway, and possible targeted therapies. The review also focuses on presenting the differences between cancer cells and normal cells in terms of metabolic phenotype. Knowledge of cancer cell metabolism is constantly evolving, and further research is needed to develop new strategies for anti-cancer therapies.

【 授权许可】

Unknown