The error‐related negativity as a neuromarker of risk or resilience in young children

Brain and Behavior

Jamie M. Lawler¹  Kristin Aho¹  Renee Lajiness‐O’Neill¹  Kate D. Fitzgerald²  Maria Muzik²  Katherine L. Rosenblum²  Yanni Liu²  Jessica Hruschak³  Ka I. Ip⁴ 

[1] Eastern Michigan University Ypsilanti MI USA;University of Michigan Ann Arbor MI USA;Wayne State University Detroit MI USA;Yale University New Haven CT USA;

关键词: anxiety;    cognitive control;    emotion regulation;    error‐related negativity;    executive functioning;   

DOI  :  10.1002/brb3.2008

来源: DOAJ

【 摘 要 】

Abstract Introduction The error‐related negativity (ERN) is a neural response that reflects error monitoring. Contradictorily, an enlarged (more negative) ERN has been cited as both a risk factor and a protective factor, which hinders its utility as a predictive indicator. The aim of the current study was to examine the associations between ERN measured in early childhood with the development of cognitive control (CC), emotion regulation, and internalizing/externalizing symptoms over 1–2 years. Methods When children were ages 5–7, EEG was collected during a Go/No‐Go task. A subset of the original participants (n = 30) were selected based on their baseline ERN in an extreme‐case design: half with high‐amplitude ERN, matched by age and sex with another group with low‐amplitude ERN. Results At follow‐up, children in the High‐Amplitude group showed better executive function, less self‐reported anxiety and depression, less affect dysregulation, more parent‐rated CC, less lability/negativity, and fewer parent‐reported externalizing problems. Many results held even when accounting for baseline levels. Further, emotion dysregulation mediated the relationship between the ERN and both anxiety and externalizing problems, while CC mediated the ERN's relationship with externalizing problems only. Conclusions These results can inform identification and intervention efforts for children at risk for psychopathology.

【 授权许可】

Unknown