Analysis of 5-hydroxytryptamine and its related indoles in cerebrospinal fluid of leukemic children by gas chromatography-mass spectrometry

Journal of Laboratory Medicine

Zhang Pingping¹  Sun Yanmei¹  Gao Jian¹  Wang Bo²  Lian Kaoqi³ 

[1] Department of Reproductive Genetic Family, Hebei General Hospital, Shijiazhuang, P.R. China;Handan College, Handan, P.R. China;School of Public Health, Hebei Medical University, Shijiazhuang, P.R. China;

关键词: 5-hydroxyindole acetic acid;    5-hydroxytryptamine;    cerebrospinal fluid;    gas chromatography-mass spectrometry;    leukemia;   

DOI  :  10.1515/labmed-2019-0156

来源: DOAJ

【 摘 要 】

It is meaningful to quantify some neurotransmitters in cerebrospinal fluid (CSF) for pathology and clinical diagnosis. The objective of this study was to develop a rapid and reliable method for detecting 5-hydroxyindole ethanol (5-HTOL), 5-hydroxyindole acetic acid (5-HIAA), 5-hydroxytryptophan (5-HTP) and 5-hydroxytryptamine (5-HT) in CSF by gas chromatography-mass spectrometry (GC-MS), and explore the clinical significance of the levels of these neurotransmitters in CSF from acute lymphoblastic leukemia (ALL).

【 授权许可】

Unknown