Endovascular Therapy for Acute Ischemic Stroke of Intracranial Atherosclerotic Origin—Neuroimaging Perspectives

Frontiers in Neurology

Oh Young Bang¹  Woo-Keun Seo¹  Pyoung Jeon²  Byung Moon Kim³ 

[1] Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea;Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea;Department of Radiology, Severance Hospital Stroke Center, Yonsei University College of Medicine, Seoul, South Korea;

关键词: atherosclerosis;    neuroimage;    endovascular therapy;    acute ischemic stroke;    intracranial;   

DOI  :  10.3389/fneur.2019.00269

来源: DOAJ

【 摘 要 】

Large vessel occlusion (LVO) due to intracranial atherosclerosis (ICAS) is a common cause of acute ischemic stroke (AIS) in Asians. Endovascular therapy (EVT) has been established as the mainstay of treatment in patients with AIS and LVO. However, only a few patients of Asian descent with ICAS-related LVO (ICAS-LVO) were included in recent randomized controlled trials of EVT for AIS. Therefore, the findings of these trials cannot be directly applied to Asian patients with ICAS-LVO. In embolic LVO due to thrombus from the heart or a more proximal vessel, rapid, and complete recanalization can be achieved in more than 70–80% of patients, and it is important to exclude patients with large cores. In contrast, patients with ICAS-LVO usually have favorable hemodynamic profiles (good collateral status, small core, and less severe perfusion deficit), but poor response to EVT (more rescue treatments and longer procedure times are required for successful recanalization due to higher rates of reocclusion). Patients with ICAS-LVO may have different anatomic (plaque, angioarchitecture), hemodynamic (collateral status), and pathophysiologic (thrombus composition) features on neuroimaging compared to patients with embolic LVO. In this review, we discuss these neuroimaging features, their clinical implications with respect to determination of EVT responses, and the need for development of specific EVT devices and procedures for patients with ICAS-LVO.

【 授权许可】

Unknown