Association of Non-Alcoholic Fatty Liver Disease and Hepatic Fibrosis with Epicardial Adipose Tissue Volume and Atrial Deformation Mechanics in a Large Asian Population Free from Clinical Heart Failure

Diagnostics

卷:12

Cheng-Ting Tsai¹  Yau-Huei Lai¹  Chung-Lieh Hung¹  Chun-Ho Yun¹  Hung-I Yeh¹  Cheng-Huang Su¹  Ta-Chuan Hung¹ 

[1] Department of Medicine, Mackay Medical College, New Taipei City 25245, Taiwan;

关键词: fatty liver;    cardiovascular disease;    fibrosis;    epicardial fat;    left atrial strain;   

DOI  :  10.3390/diagnostics12040916

来源: DOAJ

【 摘 要 】

Non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease share several cardiometabolic risk factors. Excessive visceral fat can manifest as ectopic fat depots over vital organs, such as the heart and liver. This study assessed the associations of NAFLD and liver fibrosis with cardiac structural and functional disturbances. We assessed 2161 participants using ultrasound, and categorized them as per the NAFLD Fibrosis Score into three groups: (1) non-fatty liver; (2) fatty liver with low fibrosis score; and (3) fatty liver with high fibrosis score. Epicardial fat volume (EFV) was measured through multidetector computed tomography. All participants underwent echocardiographic study, including tissue Doppler-based E/e’ ratio and speckle tracking-based left ventricular global longitudinal strain, peak atrial longitudinal strain (PALS), and atrial longitudinal strain rates during systolic, early and late-diastolic phases (ALSR_syst, ALSR_early. ALSR_late). Larger EFV, decreased e’ velocity, PALS, ALSR_syst, and ALSR_early, along with elevated E/e’ ratio, were seen in all groups, especially in those with high fibrosis scores. After multivariate adjustment for traditional risk factors and EFV, fibrosis scores remained significantly associated with elevated E/e’ ratio, LA stiffness, and decreased PALS (β: 0.06, 1.4, −0.01, all p < 0.05). Thus, NAFLD is associated with LV diastolic dysfunction and subclinical changes in LA contractile mechanics.

【 授权许可】

Unknown