Linear and Non-linear Correlations Between Serum Phosphate Level and Bone Mineral Density in Type 2 Diabetes

Frontiers in Endocrinology

卷:11

Xinhua Qu¹  Xilu Yi²  Jun Liang³  Chenhe Zhao⁴  Yinqiu Yang⁴  Yangli Ye⁴  Mingxiang Yu⁴  Jing Liang⁴  Yao Zhang⁵  Chao Ma⁶  Guangwang Liu⁶  Guiping Xu⁷ 

[1] Department of Bone and Joint Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China;

[2] Department of Endocrinology, Songjiang Central Hospital, Shanghai, China;

[3] Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical University, The Affiliated Xuzhou Hospital of Medical College of Southeast University, Xuzhou Clinical Medical College of Nanjing University of Chinese Medicine, Xuzhou, China;

[4] Department of Endocrinology, Zhongshan Hospital, Fudan University, Shanghai, China;

[5] Department of Infectious Disease, Zhongshan Hospital, Fudan University, Shanghai, China;

[6] Department of Orthopaedics, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical University, The Affiliated Xuzhou Hospital of Medical College of Southeast University, Xuzhou Clinical Medical College of Nanjing University of Chinese Medicine, Xuzhou, China;

[7] VIP Clinical Department, Fujian Provincial Hospital, Fuzhou, China;

关键词: serum phosphate;    bone mineral density;    type 2 diabetes;    bone metabolism;    fracture risk;   

DOI  :  10.3389/fendo.2020.00497

来源: DOAJ

【 摘 要 】

Introduction: Serum phosphate plays an important role in bone mineralization and might be a risk factor for many bone diseases. Patients with T2D usually have low serum phosphate level due to diet control, osmotic diuresis, and insulin stimulation. Current studies have discussed the linear association between serum phosphate and bone mineral density (BMD).Objective: We aimed to analyze both the linear and non-linear correlations between serum phosphate and BMD in patients with type 2 diabetes (T2D).Methods: We included 1,469 patients with T2D and obtained their basic information, laboratory measurements, and BMD data. Multivariate adjusted linear regression was used to analyze the linear associations, and we applied a two-piecewise linear regression model using a smoothing function to examine the non-linear association.Results: No linear correlation was found between serum phosphate and BMD in patients with T2D. In women with T2D, we found a non-linear correlation between serum phosphate level and femur neck or total hip BMD. When serum phosphate was <1.3 mmol/L, it was positively associated with femur neck and total hip BMD, whereas when phosphate was >1.3 mmol/L, it was negatively associated with femur neck BMD.Conclusions: In men with T2D, serum phosphate level was not associated with BMD. However, in women with T2D, we found a non-linear correlation between serum phosphate and femur neck or total hip BMD.

【 授权许可】

Unknown