The role of recombinant LH in women with hypo-response to controlled ovarian stimulation: a systematic review and meta-analysis

Reproductive Biology and Endocrinology

卷:17

Sandro C. Esteves¹  Ida Strina²  Giuseppe De Placido²  Fulvio Zullo²  Pasquale De Rosa²  Alessandro Conforti²  Carlo Alviggi²  Francesca Di Rella³  Alessia Fiorenza⁴ 

[1] ANDROFERT, Andrology and Human Reproduction Clinic;

[2] Department of Neuroscience, Reproductive Science and Odontostomatology, University of Naples Federico II;

[3] Department of Senology, Medical Oncology, National Cancer Institute, IRCCS “Fondazione G.Pascale”;

[4] Unit of Obstetrics and Gynaecology, Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro;

关键词: LH;    Recombinant LH;    Hypo-responders;    Assisted reproductive technologies;    In vitro fertilization;    Ovulation induction;   

DOI  :  10.1186/s12958-019-0460-4

来源: DOAJ

【 摘 要 】

Abstract Objective To study the role of recombinant human LH supplementation in women with hypo-response to ovarian stimulation. Methods We performed a systematic review and meta-analysis of prospective clinical trials in which recombinant FSH monotherapy protocols were compared with LH-supplemented protocols in hypo-responders. A search was conducted of the Scopus, MEDLINE databases without time or language restrictions. Primary outcome was clinical pregnancy rate. Results Significantly higher clinical pregnancy rates (odds ratio: 2.03, P = 0.003), implantation rates (odds ratio: 2.62, P = 0.004) and number of oocytes retrieved (weight mean differences: 1.98, P = 0.03) were observed in hypo-responders supplemented with recombinant LH versus hypo-responders who underwent FSH monotherapy. No differences in terms of mature oocytes or miscarriage rates were found between the two groups. Conclusion In conclusion, our analysis confirms that women with a hypo-response to exogenous gonadotropins might benefit from LH supplementation. However, more trials are required before a definitive conclusion can be drawn.

【 授权许可】

Unknown