Vitamin D and Gestational Diabetes Mellitus: Is There a Link?

Antioxidants

卷:8

Giuseppe Grosso¹  Michele Fichera²  MarcoMarzio Panella²  George Vilos³  Simone Garzon⁴  Pasquale de Franciscis⁵  Antonio Schiattarella⁵  Ursula Catena⁶  Péter Török⁷  Gianluca Rizzo⁸  Jan Tesarik⁹ 

[1] Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy;

[2] Department of General Surgery and Medical Surgical Specialties, University of Catania, 95124 Catania, Italy;

[3] Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Western University, London, ON N6H5W9, Canada;

[4] Department of Obstetrics and Gynecology, “Filippo del Ponte” Hospital, University of Insubria, 21100 Varese, Italy;

[5] Department of Woman, Child and General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, 81100 Naples, Italy;

[6] Division of Gynecologic Oncology, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, 00168 Rome, Italy;

[7] Faculty of Medicine, Institute of Obstetrics and Gynaecology, University of Debrecen, H-4032 Debrecen, Hungary;

[8] Independent Researcher;

[9] MARGen Clinic, 18006 Granada, Spain;

关键词: vitamin d;    gestational diabetes mellitus;    pregnancy;    nutrition;    supplements;    antenatal care;    food fortification;   

DOI  :  10.3390/antiox8110511

来源: DOAJ

【 摘 要 】

Gestational diabetes mellitus (GDM) is a very common condition among pregnant women worldwide with important metabolic implications on the mother and the offspring. Vitamin D status has been suggested to potentially play a role in GDM risk with no documented consequences for the offspring. The purpose of this article was to review currently available evidence on the relationship between vitamin D and GDM. Current evidence shows an association between vitamin D blood levels and risk of GDM, despite heterogeneity of results across studies limit the conclusions. Moreover, data from randomized controlled trials is scarce and resulting in null findings. Among the limitations to be noted, improving the standardization of dosages, the characteristics of individuals in the sample, and the appropriate outcome measurement could provide a more effective approach in understanding the relationship between vitamin D and GDM. In conclusions, despite observational studies may suggest that adequate vitamin D levels may decrease the risk of GDM compared to deficiency status, evidence from clinical trials is inadequate to draft any definitive conclusion regarding its supplementation. Future better designed randomized clinical trials taking into account a more integrated approach could provide clearer and definitive data on the outcomes of such a multifactorial condition.

【 授权许可】

Unknown