NIR-II-activated biocompatible hollow nanocarbons for cancer photothermal therapy

Journal of Nanobiotechnology

卷:19

Yinling Zhang¹  Weixiao Zhou¹  Zhourui Xu¹  Gaixia Xu¹  Mingze Ma¹  Chengbin Yang¹  Tiantian Kong¹  Weiping Wu²  Fenghua Liu²  Zan Wang²  Yucheng Wang³  Binyuan Zhao⁴  Lijian Wang⁴ 

[1] Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University;

[2] Laboratory of Thin Film Optics, Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences;

[3] School of Physics and Optoelectronic Engineering, Xidian University;

[4] State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University;

关键词: Photothermal therapy;    NIR-II;    Biocompatible;    Hollow carbon nanospheres;    Cancer treatment;   

DOI  :  10.1186/s12951-021-00884-7

来源: DOAJ

【 摘 要 】

Abstract Photothermal therapy has attracted extensive attentions in cancer treatment due to its precise spatial-temporal controllability, minimal invasiveness, and negligible side effects. However, two major deficiencies, unsatisfactory heat conversion efficiency and limited tissue penetration depth, hugely impeded its clinical application. In this work, hollow carbon nanosphere modified with polyethylene glycol-graft-polyethylenimine (HPP) was elaborately synthesized. The synthesized HPP owns outstanding physical properties as a photothermal agent, such as uniform core-shell structure, good biocompatibility and excellent heat conversion efficiency. Upon NIR-II laser irradiation, the intracellular HPP shows excellent photothermal activity towards cancer cell killing. In addition, depending on the large internal cavity of HPP, the extended biomedical application as drug carrier was also demonstrated. In general, the synthesized HPP holds a great potential in NIR-II laser-activated cancer photothermal therapy.

【 授权许可】

Unknown