Functional Status Is Associated With Prefrontal Cortex Activation in Gait in Subacute Stroke Patients: A Functional Near-Infrared Spectroscopy Study

Frontiers in Neurology

卷:11

Eric Hermand¹  Anaick Perrochon²  Olivier Dupuy³  Maxence Compagnat⁴  Jean-Christophe Daviet⁴  Jean-Yves Salle⁴ 

[1] Laboratoire EA 7369 URePSSS “Unité de Recherche Pluridisciplinaire Sport, Santé, Société”, Université du Littoral Côte d'Opale, Dunkerque, France;

[2] Laboratoire EA6310 HAVAE “Handicap, Activité, Vieillissement, Autonomie, Environnement,” Université de Limoges, Limoges, France;

[3] Laboratoire EA6314 MOVE “Mobilité Vieillissement et Exercice, ” Université de Poitiers, Poitiers, France;

[4] Médecine Physique et de Réadaptation, CHU de Limoges, Limoges, France;

关键词: functional near-infrared spectroscopy;    dual task;    gait;    cognition;    prefrontal cortex;   

DOI  :  10.3389/fneur.2020.559227

来源: DOAJ

【 摘 要 】

Increasing cerebral oxygenation, more precisely the overactivation of the prefrontal cortex (PFC), reflects cortical control of gait in stroke disease. Studies about the relationship between brain activation and the functional status in stroke patients remain scarce. The aim of this study was to compare brain activation, gait parameters, and cognitive performances in single and dual tasks according to the functional status in subacute stroke patients. Twenty-one subacute stroke patients were divided in two groups according to Barthel Index (“low Barthel” and “high Barthel”) and randomly performed ordered walking, cognitive task (n-back task), and dual tasks (walking + n-back task). We assessed gait performances (speed, variability) using an electronic walkway system and cerebral oxygenation (ΔO2Hb) by functional near-infrared spectroscopy. Patients with better functional status (high Barthel) showed a lower PFC activation (ΔO2Hb) and better gait parameters in single and dual tasks compared to low-Barthel patients, who exhibited decreased gait performances despite a higher PFC activation, especially in the unaffected side (P < 0.001). PFC overactivation in less functional subacute stroke patients may be due to the loss of stepping automaticity. Our results underline the interest of proposing rehabilitation programs focused on walking, especially for patients with low functional capacity.

【 授权许可】

Unknown