Regulation of Translation in the Protozoan Parasite Leishmania

International Journal of Molecular Sciences

卷:21

ZemfiraN. Karamysheva¹  SneiderAlexander Gutierrez Guarnizo²  AndreyL. Karamyshev² 

[1] Department of Biological Sciences, Texas Tech University, Lubbock, TX 79409, USA;

[2] Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA;

关键词: Leishmania parasites;    unicellular protozoa;    parasite differentiation;    translational control;    selective translation;    RNA-binding proteins;   

DOI  :  10.3390/ijms21082981

来源: DOAJ

【 摘 要 】

Leishmaniasis represents a serious health problem worldwide and drug resistance is a growing concern. Leishmania parasites use unusual mechanisms to control their gene expression. In contrast to many other species, they do not have transcriptional regulation. The lack of transcriptional control is mainly compensated by post-transcriptional mechanisms, including tight translational control and regulation of mRNA stability/translatability by RNA-binding proteins. Modulation of translation plays a major role in parasite survival and adaptation to dramatically different environments during change of host; however, our knowledge of fine molecular mechanisms of translation in Leishmania remains limited. Here, we review the current progress in our understanding of how changes in the translational machinery promote parasite differentiation during transmission from a sand fly to a mammalian host, and discuss how translational reprogramming can contribute to the development of drug resistance.

【 授权许可】

Unknown