The Correlation between the Expression of EGFR in Tumor Tissue and in Peripheral Blood in Non-small Cell Lung Cancer Patients

Chinese Journal of Lung Cancer

卷:13

关键词: Lung neoplasms;    EGFR;    Plasma;    Tumor tissue;    RT-PCR;   

DOI  :  

来源: DOAJ

【 摘 要 】

Background and objective It has been proven that EGFR plays an important role in cell proliferation, and has predictive values for diagnosis and prognosis. The aim of this study is to investigate the correlation between the expression of EGFR in tumor tissue and peripheral blood in non-small cell lung cancer (NSCLC) patients. Methods The expression of EGFR was analyzed by real-time RT-PCR in 46 NSCLC tumor tissues and by ELISA in peripheral blood, compared with 10 patients with benign pulmonary diseases as control. Results Linear correlation analysis revealed there was a correlation of the expression of EGFR protein between peripheral blood and tumor tissue (P=0.016, R2=0.83). Conclusion The expression of EGFR mRNA in tumor tissue was positively correlated with EGFR protein in plasma. Detection of protein in plasma may replace that in tumor tissue, providing a quicker and easier examination method for the patients lacking biopsy tissue.

【 授权许可】

Unknown