Mismatch Repair System Genomic Scars in Gastroesophageal Cancers: Biology and Clinical Testing

Gastrointestinal Disorders

卷:2

Gianluca Lopez¹  Nicola Fusco¹  Konstantinos Venetis¹  Elham Sajjadi¹ 

[1] Division of Pathology, IEO, European Institute of Oncology IRCCS, University of Milan, Via Giuseppe Ripamonti 435, 20141 Milan, Italy;

关键词: mismatch repair;    microsatellite instability;    biomarkers;    immunotherapy gastroesophageal cancer;    gastric cancer;   

DOI  :  10.3390/gidisord2040031

来源: DOAJ

【 摘 要 】

Alterations in the mismatch repair (MMR) system result in genomic instability, neoantigen production, and immune response in cancer. There is evidence that gastroesophageal tumors with MMR deficiency may be susceptible to immune-checkpoint inhibitors treatment, especially in those presenting at advanced-stage disease. Although a number of biomarkers have been developed in histology-agnostic settings to assess MMR status, there is evidence that a tumor-specific testing approach would improve the selection of patients for immunotherapy. However, no testing methods have been developed specifically for gastroesophageal cancers so far. Here, we discuss the state of the art, current advances, and future perspectives of MMR-related biomarkers’ biologic and clinical role in gastroesophageal cancers.

【 授权许可】

Unknown