Real-Life Experience with Pomalidomide plus Low-Dose Dexamethasone in Patients with Relapsed and Refractory Multiple Myeloma: A Retrospective and Prospective Study

Medicina

卷:57

Irene Attucci¹  Elisabetta Antonioli¹  Giuseppe Formica¹  Sara Galimberti²  Maria Livia Del Giudice²  Mario Petrini²  Francesco Ghio²  Enrico Orciuolo²  Gabriele Buda²  Sara Ciofini³  Monica Bocchia³  Alessandro Gozzetti³  Giulia Fontanelli⁴  Veronica Candi⁵ 

[1] Haematology Unit, Careggi Hospital-University of Florence, Largo Brambilla 3, 50134 Florence, Italy;

[2] Hematology Unit, Department of Clinical And Experimental Medicine, University of Pisa, 56126 Pisa, Italy;

[3] Hematology Unit, University of Siena, Azienda Ospedaliera Universitaria Senese Siena, 53100 Siena, Italy;

[4] UOC Oncologia, UOS Ematologia, Ospedale San Giuseppe, 50053 Empoli, Italy;

[5] UOS Ematologia, San Donato Hospital, ASL8, 52100 Arezzo, Italy;

关键词: pomalidomide;    dexamethasone;    multiple myeloma;    immunomodulatory therapy;    real-world clinical trials;   

DOI  :  10.3390/medicina57090900

来源: DOAJ

【 摘 要 】

Background and Objectives: The treatment of Myeloma after the second relapse is still challenging. The aim of the study was to investigate the outcomes of the POM-DEX regimen in real clinical practice. Materials and Methods: We retrospectively and prospectively analyzed 121 patients with MM treated with POM-DEX in three Italian sites in Tuscany. We assessed the efficacy based on IMWG Uniform Response Criteria in 106 patients who had received at least two courses of the POM-DEX regimen. The median time from diagnosis to use of POM-DEX was 65 months. POM-DEX median use was in the fourth-line therapy. 63.6% were exposed to lenalidomide or thalidomide, 40.5% to bortezomib or carfilzomib or ixazomib, 5.8% to mAbs in the immediately preceding line of therapy. Results: ORR was 43.4%. Median PFS and OS were 8.5 and 14 months. Eighty-nine patients received more than two courses: their median PFS and OS were 11 and 16 months. When used as the third line of therapy, median PFS and OS were 9 and 20 months and, when patients received POM-DEX for more than two courses, median PFS and OS were 14.5 and 22.5 months. Conclusions: POM-DEX is effective in RRMM, regardless of the latest exposure to IMiDs, PIs, and mAbs in the previous line of therapy.

【 授权许可】

Unknown