Antibacterial Nanostructured Ti Coatings by Magnetron Sputtering: From Laboratory Scales to Industrial Reactors

Nanomaterials

卷:9

Isabel Izquierdo-Barba¹  Daniel Arcos¹  María Vallet-Regi¹  Víctor Rico²  AgustínR. González-Elipe²  Aurelio García-Valenzuela²  Rafael Alvarez²  Alberto Palmero²  MaríaU. González³  JoséM. García-Martín³  Sandra Muñoz-Piña⁴  Iván Fernández-Martínez⁴ 

[1] Dpto de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria Hospital 12 de Octubre i+12, Plaza Ramón y Cajal s/n, 28040 Madrid, Spain;

[2] Instituto de Ciencia de Materiales de Sevilla (CSIC-US), Américo Vespucio 49, 41092 Seville, Spain;

[3] Instituto de Micro y Nanotecnología, IMN-CNM, CSIC (CEI UAM + CSIC), Isaac Newton 8, 28760 Tres Cantos, Madrid, Spain;

[4] Nano4Energy SLNE, C/Jose Gutierrez Abascal 2, 28006 Madrid, Spain;

关键词: magnetron sputtering;    oblique angle deposition;    nanostructured titanium thin films;    antibacterial coatings;    osteoblast proliferation;    industrial scale;   

DOI  :  10.3390/nano9091217

来源: DOAJ

【 摘 要 】

Based on an already tested laboratory procedure, a new magnetron sputtering methodology to simultaneously coat two-sides of large area implants (up to ~15 cm²) with Ti nanocolumns in industrial reactors has been developed. By analyzing the required growth conditions in a laboratory setup, a new geometry and methodology have been proposed and tested in a semi-industrial scale reactor. A bone plate (DePuy Synthes) and a pseudo-rectangular bone plate extracted from a patient were coated following the new methodology, obtaining that their osteoblast proliferation efficiency and antibacterial functionality were equivalent to the coatings grown in the laboratory reactor on small areas. In particular, two kinds of experiments were performed: Analysis of bacterial adhesion and biofilm formation, and osteoblasts−bacteria competitive in vitro growth scenarios. In all these cases, the coatings show an opposite behavior toward osteoblast and bacterial proliferation, demonstrating that the proposed methodology represents a valid approach for industrial production and practical application of nanostructured titanium coatings.

【 授权许可】

Unknown