Nutrients | 卷:13 |
Effect of Oat β-Glucan on Affective and Physical Feeling States in Healthy Adults: Evidence for Reduced Headache, Fatigue, Anxiety and Limb/Joint Pains | |
Adish Ezatagha1  JaniceE. Campbell1  ThomasM. S. Wolever1  AlexandraL. Jenkins1  ElHadji Dioum2  Maike Rahn2  YiFang Chu2  | |
[1] Formerly GI Labs, INQUIS Clinical Research, Ltd., Toronto, ON M5C 2N8, Canada; | |
[2] Quaker Oats Center of Excellence, PepsiCo R&D Nutrition, Barrington, IL 60010, USA; | |
关键词: randomized clinical trial; humans; symptoms; gastrointestinal tract; musculo-skeletal system; oats; | |
DOI : 10.3390/nu13051534 | |
来源: DOAJ |
【 摘 要 】
The gastrointestinal (GI) side-effects of dietary fibers are recognized, but less is known about their effects on non-GI symptoms. We assessed non-GI symptoms in a trial of the LDL-cholesterol lowering effect of oat β-glucan (OBG). Participants (n = 207) with borderline high LDL-cholesterol were randomized to an OBG (1 g OBG, n = 104, n = 96 analyzed) or Control (n = 103, n = 95 analyzed) beverage 3-times daily for 4 weeks. At screening, baseline, 2 weeks and 4 weeks participants rated the severity of 16 non-GI symptoms as none, mild, moderate or severe. The occurrence and severity (more or less severe than pre-treatment) were compared using chi-squared and Fisher’s exact test, respectively. During OBG treatment, the occurrence of exhaustion and fatigue decreased versus baseline (p < 0.05). The severity of headache (2 weeks, p = 0.032), anxiety (2 weeks p = 0.059) and feeling cold (4 weeks, p = 0.040) were less on OBG than Control. The severity of fatigue and hot flashes at 4 weeks, limb/joint pain at 2 weeks and difficulty concentrating at both times decreased on OBG versus baseline. High serum c-reactive-protein and changes in c-reactive-protein, oxidized-LDL, and GI-symptom severity were associated with the occurrence and severity of several non-GI symptoms. These data provide preliminary, hypothesis-generating evidence that OBG may reduce several non-GI symptoms in healthy adults.
【 授权许可】
Unknown