Yacon flour (Smallanthus sonchifolius) attenuates intestinal morbidity in rats with colon cancer

Journal of Functional Foods

卷:37

Neuza Maria Brunoro Costa¹  Maria das Graças Vaz Tostes²  Louisiane de Carvalho Nunes²  Mariana Grancieri²  Daniela Silva de Oliveira²  Thaísa Agrizzi Veridiano²  Mirelle Lomar Viana²  Letícia de Nadai Marcon³ 

[1] Corresponding author at: Department of Pharmacy and Nutrition, Center for Exact, Natural and Health Sciences, Federal University of Espirito Santo, Alto Universitário, S/N, Guararema, P.O. Box: 16, 29500-000 Alegre, ES, Brazil.;

[2] Department of Pharmacy and Nutrition, Center for Exact, Natural and Health Sciences, Federal University of Espirito Santo, Alto Universitário, S/N, Guararema, 29500-000 Alegre, ES, Brazil;

[3] Department of Veterinary Medicine, Center of Agrarian Sciences and Engineering, Federal University of Espirito Santo, Alto Universitário, S/N, Guararema, 29500-000 Alegre, ES, Brazil;

关键词: Fructooligosaccharides;    Prebiotics;    Intestinal permeability;    SCFA;    pH;   

DOI  :  

来源: DOAJ

【 摘 要 】

Yacon flour (YF) (Smallanthus sonchifolius) is source of fructooligosaccharides (FOS) which are prebiotic with effects unknown in the colorectal cancer (CRC). This study investigated the intestinal effects of supplementation with 7.5% FOS from YF for 8 weeks on CRC induced by 1.2-dimethylhydrazine (25 mg/kg/body weight) in male Wistar rats. The animals were divided in groups: S (without YF and without induced CRC, n = 10), Y (with YF and without induced CRC, n = 10), C (without YF and with induced CRC, n = 10) and CY (with YF and with induced CRC, n = 10). The animals that received YF had a percentage reduction of aberrant crypts focus in more than 40%, lower intestinal permeability, luminal content more acidic and with higher concentrations of SCFA. In addition, there was an increase in the depth and number of colonic crypts. In conclusion, we observed that YF promoted beneficial effects on the intestinal health of animals with induced CRC.

【 授权许可】

Unknown