Skin manifestations of gefitinib and the association with survival of advanced non-small-cell lung cancer in Taiwan

Dermatologica Sinica

卷:29

Yi-Hua Liao¹  Hsiao-Chin Chen¹  Shiou-Han Wang¹  Hsien-Ching Chiu¹  Chih-Chieh Chan¹  Chia-Yu Chu¹  Chih-Hsin Yang²  Fu-Chang Hu³ 

[1] Department of Dermatology, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan;

[2] Department of Oncology, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan;

[3] National Center of Excellence for General Clinical Trial and Research, National Taiwan University Hospital and College of Public Health, National Taiwan University, Taipei, Taiwan;

关键词: Gefitinib;    Non-small-cell lung cancer;    Paronychia;    Predictive factor;    Skin toxicities (cutaneous adverse reactions);   

DOI  :  10.1016/j.dsi.2011.02.003

来源: DOAJ

【 摘 要 】

Background: Epidermal growth factor receptor antagonists, such as gefitinib, erlotinib, and cetuximab, have been used in treating carcinomas. The efficacies have been proposed to correlate with skin reactions, but the most important predictive indicator is still unknown. Our aim was to investigate the types of skin toxicities and to analyze the major therapeutic predictive indicators in Taiwan.Methods: A retrospective analysis was used to study 68 patients with advanced non-small-cell lung cancer receiving gefitinib.Results: Acneiform eruption (41.2%), xerosis (38.2%), pruritus (26.5%), and paronychia (16.2%) composed most of the skin reactions. The univariate analysis revealed paronychia as the most substantial survival predictive indicator (p=0.0427). In the multivariate analysis, older patients with paronychia had better prognosis (p=0.0050). Women tended to develop paronychia (p=0.1098). Xerosis positively correlated with paronychia (p=0.0082).Conclusion: Paronychia is the most indicative survival predictive factor among the skin manifestations, and it correlates with age, gender, and xerosis. Elucidation of the relationship between cutaneous reactions can provide information on the epidermal growth factor receptor signaling mechanism of skin.

【 授权许可】

Unknown