Non-additive Effects in Genomic Selection

Frontiers in Genetics

卷:9

Miguel A. Toro¹  Andres Legarra³  Zulma G. Vitezica⁴  Luis Varona⁵ 

[1] Departamento Producción Agraria, ETS Ingeniería Agronómica, Alimentaria y de Biosistemas, Universidad Politécnica de Madrid, Madrid, Spain;

[2] Departamento de Anatomía, Embriología y Genética Animal, Universidad de Zaragoza, Zaragoza, Spain;

[3] Génétique Physiologie et Systèmes d'Elevage (GenPhySE), Institut National de la Recherche Agronomique de Toulouse, Castanet-Tolosan, France;

[4] Génétique Physiologie et Systèmes d'Elevage (GenPhySE), Université de Toulouse, Castanet-Tolosan, France;

[5] Instituto Agroalimentario de Aragón (IA2), Zaragoza, Spain;

关键词: genomic selection;    dominance;    epistasis;    crossbreeding;    genetic evaluation;   

DOI  :  10.3389/fgene.2018.00078

来源: DOAJ

【 摘 要 】

In the last decade, genomic selection has become a standard in the genetic evaluation of livestock populations. However, most procedures for the implementation of genomic selection only consider the additive effects associated with SNP (Single Nucleotide Polymorphism) markers used to calculate the prediction of the breeding values of candidates for selection. Nevertheless, the availability of estimates of non-additive effects is of interest because: (i) they contribute to an increase in the accuracy of the prediction of breeding values and the genetic response; (ii) they allow the definition of mate allocation procedures between candidates for selection; and (iii) they can be used to enhance non-additive genetic variation through the definition of appropriate crossbreeding or purebred breeding schemes. This study presents a review of methods for the incorporation of non-additive genetic effects into genomic selection procedures and their potential applications in the prediction of future performance, mate allocation, crossbreeding, and purebred selection. The work concludes with a brief outline of some ideas for future lines of that may help the standard inclusion of non-additive effects in genomic selection.

【 授权许可】

Unknown