[3+2] Cycloaddition of Tosylmethyl Isocyanide with Styrylisoxazoles: Facile Access to Polysubstituted 3-(Isoxazol-5-yl)pyrroles

Molecules

卷:22

Xianxiu Xu¹  Dawei Zhang²  Xueming Zhang² 

[1] College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Normal University, Jinan 250014, China;

[2] College of Chemistry, Jilin University, Changchun 130012, China;

关键词: isoxazol-5-ylpyrroles;    [3+2]cycloaddition;    TosMIC;    3-methyl-4-nitro-5-styrylisoxazoles;   

DOI  :  10.3390/molecules22071131

来源: DOAJ

【 摘 要 】

A facile access to polysubstituted 3-(isoxazol-5-yl)pyrroles was developed through [3+2] cycloaddition of tosylmethyl isocyanide (TosMIC) and styrylisoxazoles. In the presence of KOH, various styrylisoxazoles reacted smoothly with tosylmethyl isocyanide and analogs to deliver a wide range of 3-(isoxazol-5-yl)pyrroles at ambient temperature. This transformation is operationally simple, high-yielding, and displays broad substrate scope.

【 授权许可】

Unknown