Functional Role of Transient Receptor Potential Channels in Immune Cells and Epithelia

Frontiers in Immunology

卷:9

Carl Weidinger¹  Cansu Yerinde¹  Korina Alliger²  Matthias Agop Engel²  Stefan Wirtz²  Mohammad Khalil²  Christoph Becker² 

[1] Charité Universitätsmedizin Berlin, Campus Benjamin Franklin Medizinische Klinik für Gastroenterologie, Infektiologie und Rheumatologie, Berlin, Germany;

[2] Universitätsklinikum Erlangen, Medizinische Klinik 1, Erlangen, Germany;

关键词: colitis;    macrophages;    cytokines;    neuropeptides;    neurogenic inflammation;    nociception;   

DOI  :  10.3389/fimmu.2018.00174

来源: DOAJ

【 摘 要 】

Transient receptor potential (TRP) ion channels are widely expressed in several tissues throughout the mammalian organism. Originally, TRP channel physiology was focusing on its fundamental meaning in sensory neuronal function. Today, it is known that activation of several TRP ion channels in peptidergic neurons does not only result in neuropeptide release and consecutive neurogenic inflammation. Growing evidence demonstrates functional extra-neuronal TRP channel expression in immune and epithelial cells with important implications for mucosal immunology. TRP channels maintain intracellular calcium homeostasis to regulate various functions in the respective cells such as nociception, production and release of inflammatory mediators, phagocytosis, and cell migration. In this review, we provide an overview about TRP-mediated effects in immune and epithelial cells with an emphasis on mucosal immunology of the gut. Crosstalk between neurons, epithelial cells, and immune cells induced by activation of TRP channels orchestrates the immunologic response. Understanding of its molecular mechanisms paves the way to novel clinical approaches for the treatment of various inflammatory disorders including IBD.

【 授权许可】

Unknown