Incidence of Thyroid Cancer in Italian Contaminated Sites

International Journal of Environmental Research and Public Health

卷:18

AIRTUM Working Group¹  Marta Benedetti²  Ivano Iavarone²  Amerigo Zona²  Paolo Contiero³  Eleonora D’Armiento⁴ 

[1] ;

[2] Department of Environment and Health, Istituto Superiore di Sanità, 00161 Rome, Italy;

[3] Environmental Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy;

[4] Internal Medicine Unit, Department of Medico-Surgical Sciences and Biotechnologies, ICOT Hospital, University of Rome, 04100 Latina, Italy;

关键词: thyroid cancer;    incidence;    endocrine disruptors;    environmental exposure;   

DOI  :  10.3390/ijerph18010191

来源: DOAJ

【 摘 要 】

Some human literature suggests a possible role of endocrine disruptors (EDs) exposure in thyroid cancer (TC) development. We investigated TC incidence in selected Italian National Priority Contaminated Sites (NPCS) with documented presence of EDs considered thyroid carcinogens. Adjusted Standardized Incidence Ratios (SIRs), with their 90% confidence intervals, were computed by gender, and age-specific groups (aged 15–39 years, and 40 years or over) for each NPCS in the period 2006 to 2013. In the age group of 15–39 years, a significant excess of TC risk was found in two NPCSs in males; non-significant excess risks were observed in four NPCSs in males, and in five in females. In the age group of 40 years and over, significant excess risks were found in six NPCSs in males and in seven NPCSs in females; non-significant excess risks were identified in two NPCSs in males and females. The findings of several excesses in incidence, mainly observed in adults aged 40 years or over, are suggestive of a possible adverse effect associated with residence in NPCSs, even if a role of other factors cannot be excluded, due to the adoption of an ecological study design. Future analytical studies are needed to clarify if EDs are a TC risk factor for individuals living in NPCSs.

【 授权许可】

Unknown