Recent Achievements in Total Synthesis for Integral Structural Revisions of Marine Natural Products

Marine Drugs

卷:20

Seung-Mann Paek¹  Jonghoon Kim²  Min Woo Ha³ 

[1] College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, 501 Jinju-daero, Jinju 52828, Gyeongnam-do, Korea;

[2] Department of Chemistry, Soongsil University, 369 Sangdo-ro, Dongjak-gu, Seoul 06978, Korea;

[3] Jeju Research Institute of Pharmaceutical Sciences, College of Pharmacy, Jeju National University, 102 Jejudaehak-ro, Jeju 63243, Jeju-do, Korea;

关键词: marine natural product;    total synthesis;    structural revision;    structure elucidation;   

DOI  :  10.3390/md20030171

来源: DOAJ

【 摘 要 】

A great effort to discover new therapeutic ingredients is often initiated through the discovery of the existence of novel marine natural products. Since substances produced by the marine environment might be structurally more complex and unique than terrestrial natural products, there have been cases of misassignments of their structures despite the availability of modern spectroscopic and computational chemistry techniques. When it comes to refutation to erroneously or tentatively proposed structures empirical preparations through organic chemical synthesis has the greatest contribution along with close and sophiscated inspection of spectroscopic data. Herein, we analyzed the total synthetic studies that have decisively achieved in revelation of errors, ambiguities, or incompleteness of the isolated structures of marine natural products covering the period from 2018 to 2021.

【 授权许可】

Unknown