Clinical and experimental efficacy of gemtuzumab ozogamicin in core binding factor acute myeloid leukemia

Hematology Reports

卷:9

Andrea Piccin¹  Michele Gottardi²  Filippo Gherlinzoni²  Federico Mosna²  Cristina Papayannidis³  Giovanni Martinelli³  Marino Clavio⁴  Anna Candoni⁵  Fabio Benedetti⁶  Cristina Tecchio⁶  Marta Campo dell’Orto⁷  Sergio De Angeli⁸ 

[1] Department of Hematology, General Hospital, Bolzano;

[2] Department of Hematology, General Hospital, Treviso;

[3] Department of Hematology, Institute “L.A. Seragnoli,” University of Bologna;

[4] Department of Hematology, University of Genoa;

[5] Department of Hematology, University of Udine;

[6] Department of Hematology, University of Verona;

[7] Department of Pathology, General Hospital, Treviso;

[8] Laboratory of Cell Cryopreservation, General Hospital, Treviso;

关键词: Core binding factor;    acute myeloid leukemia;    gemtuzumab ozogamicin;    immunotherapy;    autologous stem cell transplantation;   

DOI  :  10.4081/hr.2017.7028

来源: DOAJ

【 摘 要 】

Leukemia-initiating cells of core binding factor (CBF) acute myeloid leukemia (AML) likely derive from early committed hematopoietic precursors expressing CD33. As such, targeting CD33 could ameliorate the chance of cure of CBF AML patients. We compared 12 CBF AML patients treated with Fludarabine, Cytarabine, Idarubicin and Gemtuzumab Ozogamicin (FLAI-GO regimen) with 25 CBF AML patients treated with the same schedule, but without GO. With the limit of small numbers, we observed a consistent trend toward better overall survival, disease free survival and event free survival in the FLAI-GO group. We also demonstrated the ability of GO to induce the disappearance in vitro of the AML1-ETO molecular transcript in a polymerase chain reaction-positive graft without decreasing the clonogenic potential of CD34+/CD38- cells. This represent the proof of principle for using GO in a purging strategy before autologous stem cell transplantation. Therefore, our data argue in favor of the reinstitution of GO in the therapy of CBF AML.

【 授权许可】

Unknown