Manganese/bipyridine-catalyzed non-directed C(sp3)–H bromination using NBS and TMSN3

Beilstein Journal of Organic Chemistry

卷:17

Takeru Torigoe¹  Kumar Sneh¹  Yoichiro Kuninobu¹ 

[1] Department of Molecular and Material Sciences, Interdisciplinary Graduate School of Engineering Sciences, Kyushu University, 6-1 Kasugakoen, Kasuga-shi, Fukuoka 816-8580, Japan;

关键词: bromination;    c–h transformation;    hydrogen abstraction;    manganese;    radical;   

DOI  :  10.3762/bjoc.17.74

来源: DOAJ

【 摘 要 】

A Mn(II)/bipyridine-catalyzed bromination reaction of unactivated aliphatic C(sp3)−H bonds has been developed using N-bromosuccinimide (NBS) as the brominating reagent. The reaction proceeded in moderate-to-good yield, even on a gram scale. The introduced bromine atom can be converted into fluorine and allyl groups.

【 授权许可】

Unknown