The Clinical and Neuropathological Features of Sporadic (Late-Onset) and Genetic Forms of Alzheimer’s Disease

Journal of Clinical Medicine

卷:10

Isabel C. H. Clare¹  Eva Carrillo Félez¹  Shahid H. Zaman¹  Tanzil Rujeedawa¹  Antonia Coppus²  Andre Strydom³  Johannes Levin⁴  Anne-Sophie Rebillat⁵  Juan Fortea⁶ 

[1] Cambridge Intellectual & Developmental Disabilities Research Group, Department of Psychiatry, University of Cambridge, Cambridge CB2 8PQ, UK;

[2] Department for Primary and Community Care, Department of Primary and Community Care (149 ELG), Radboud University Nijmegen Medical Center, P.O. Box 9101, 6525 GA Nijmegen, The Netherlands;

[3] Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London SE5 8AF, UK;

[4] Department of Neurology, Ludwig-Maximilians-Universität München, 80539 Munich, Germany;

[5] Geriatrics, Institut Jérôme Lejeune, 75015 Paris, France;

[6] Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autònoma de Barcelona, 08193 Barcelona, Spain;

关键词: late-onset Alzheimer’s disease;    down syndrome;    autosomal dominant Alzheimer ’s disease;    clinical features;    neuropathology;   

DOI  :  10.3390/jcm10194582

来源: DOAJ

【 摘 要 】

The purpose of this review is to compare and highlight the clinical and pathological aspects of genetic versus acquired Alzheimer’s disease: Down syndrome-associated Alzheimer’s disease in (DSAD) and Autosomal Dominant Alzheimer’s disease (ADAD) are compared with the late-onset form of the disease (LOAD). DSAD and ADAD present in a younger population and are more likely to manifest with non-amnestic (such as dysexecutive function features) in the prodromal phase or neurological features (such as seizures and paralysis) especially in ADAD. The very large variety of mutations associated with ADAD explains the wider range of phenotypes. In the LOAD, age-associated comorbidities explain many of the phenotypic differences.

【 授权许可】

Unknown