Periodontitis decreases the antiatherogenic potency of high density lipoprotein

Journal of Lipid Research

卷:45

Georg Alfthan¹  Jouko Sundvall¹  Timo Palosuo²  Tiina Vilkuna-Rautiainen²  Matti Jauhiainen³  Kimmo Mattila³  Sirkka Asikainen⁴  Pirkko J. Pussinen⁴  Marja Vesanen⁴ 

[1] Adhesion Center/Oral Microbiology, Department of Medicine and Odontology, Umeå University, Umeå, Sweden;

[2] Department of Health and Functional Ability, National Public Health Institute, Helsinki, Finland;

[3] Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland;

[4] Institute of Dentistry, University of Helsinki, and Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital, Helsinki, Finland;

关键词: HDL metabolism;    atherosclerosis;    reverse cholesterol transport;    cholesterol efflux;    inflammation;   

DOI  :  

来源: DOAJ

【 摘 要 】

Periodontitis, a consequence of persistent bacterial infection and chronic inflammation, has been suggested to predict coronary heart disease (CHD). The aim of this study was to investigate the impact of periodontitis on HDL structure and antiatherogenic function in cholesterol efflux in vitro. HDL was isolated from 30 patients (age 43.6 ± 6.1 years, mean ± SD) with periodontitis before and after (3.2 ± 1.4 months) periodontal treatment. The capacity of HDL for cholesterol efflux from macrophages (RAW 264.7), HDL composition, and key proteins of HDL metabolism were determined. After periodontal treatment, phospholipid transfer protein (PLTP) activity was 6.2% (P < 0.05) lower, and serum HDL cholesterol concentration, PLTP mass, and cholesteryl ester transfer protein activity were 10.7% (P < 0.001), 7.1% (P = 0.078), and 19.4% (P < 0.001) higher, respectively. The mean HDL2/HDL3 ratio increased from 2.16 ± 0.87 to 3.56 ± 0.48 (P < 0.05). HDL total phospholipid mass and sphingomyelin-phosphatidylcholine ratio were 7.4% (P < 0.05) and 36.8% (P < 0.001) higher, respectively. The HDL-mediated cholesterol efflux tended to be higher after periodontal treatment; interestingly, this increase was significant (P < 0.05) among patients whose C-reactive protein decreased (53.7% reduction, P = 0.015) and who were positive by PCR for Actinobacillus actinomycetemcomitans.These results suggest that periodontitis causes similar, but milder, changes in HDL metabolism than those that occur during the acute-phase response and that periodontitis may diminish the antiatherogenic potency of HDL, thus increasing the risk for CHD.

【 授权许可】

Unknown