Evaluation of buccal damage associated with acute inhalation exposure to 2,4-dichlorophenoxyacetic acid (2,4-D) in mice

BMC Veterinary Research

卷:16

Gisele Alborghetti Nai¹  Renata Calciolari Rossi²  José Luiz Santos Parizi³  Amanda Jodas Tolardo⁴  Ana Carolina Gomes Lisboa⁴  Bruna Barravieira⁴  Fabíola de Azevedo Mello⁵ 

[1]Department of Pathology, Graduate Program in Animal Science, Universidade do Oeste Paulista (UNOESTE)

[2]|Department of Pathology, Graduate Program on Environment and Regional Development, Universidade do Oeste Paulista (UNOESTE)

[3]|Department of Pathology, Universidade do Oeste Paulista (UNOESTE)

[4]|Faculty of Dentistry, Universidade do Oeste Paulista (UNOESTE)

[5]|Graduate Program in Animal Science, Universidade do Oeste Paulista (UNOESTE)

关键词: Leukoplakia;    oral;    Inflammation;    Mast cells;    Pesticide exposure;    Environmental exposure;   

DOI  :  10.1186/s12917-020-02461-w

来源: DOAJ

【 摘 要 】

Abstract Background The herbicide dichlorophenoxyacetic acid (2,4-D) is one of the most widely used crop spraying products in the world. Some pesticides induce the degranulation of mast cells and increase allergic responses. This is the first study to evaluate the damage to the oral mucosa after an experimental simulation of environmental inhalation exposure to the 2,4-D herbicide. The aim of this study was evaluate the possible oral damage caused by acute inhalation exposure to the herbicide 2,4-D. Results There was a difference between the exposure concentrations in relation to tissue congestion intensity (p = 0.002) and mast cell counts (p = 0.002), a difference in the evaluation of the interaction between the exposure concentrations and nebulization time in the dorsum epithelium thickness (p = 0.013), and a significant correlation between the epithelial thickness and the number of nucleoli organizing regions on the dorsum of the tongue (p = 0.048). Conclusions Even after acute exposure, the herbicide 2,4-D had the potential to damage the oral epithelium, especially at higher doses.

【 授权许可】

Unknown