Electrochemical Detection of a Local Anesthetic Dibucaine at Arrays of Liquid|Liquid MicroInterfaces

Chemosensors

卷:9

EissaMohamed Almbrok¹  NorAzah Yusof¹  Ruzniza Mohd Zawawi¹  Jaafar Abdullah¹ 

[1] Department of Chemistry, Faculty of Science, University Putra Malaysia, Serdang 43400, Selangor, Malaysia;

关键词: ion transfer;    dibucaine;    microinterfaces;    voltammetry;    drugs monitoring;   

DOI  :  10.3390/chemosensors9010015

来源: DOAJ

【 摘 要 】

Electrochemical characterization and detection of protonated dibucaine (${\mathrm{DIC}}^{+}$) at microinterface array across water|1,6-dichlorohexane were performed using cyclic voltammetry (CV) and differential pulse voltammetry (DPV). Some thermodynamic parameters of dibucaine, such as the standard transfer potential, the Gibbs energy of transfer and the partition coefficient, were estimated by CV. In addition to the analytical parameters, the impact of bovine serum albumin (BSA) on dibucaine detection (in artificial serum matrices) was also investigated. DPV was applied to detect a lower concentration of ${\mathrm{DIC}}^{+},$ resulting in a detection limit of 0.9 ± 0.06 µM. While the presence of BSA affected CV, demonstrated as reduced current responses, DPV was confirmed to be an efficient method for lowering concentrations of the dibucaine detection in the artificial serum matrix in the presence of BSA, with a limit of detection (LOD) of 1.9 ± 0.12 µM.

【 授权许可】

Unknown