Blueberries’ Impact on Insulin Resistance and Glucose Intolerance

Antioxidants

卷:5

April J. Stull¹ 

[1] Department of Human Ecology, University of Maryland Eastern Shore, Princess Anne, MD 21853, USA;

关键词: blueberries;    bilberries;    strawberries;    cranberries;    berries;    anthocyanins;    diabetes;    insulin;    glucose;    diabetes;   

DOI  :  10.3390/antiox5040044

来源: DOAJ

【 摘 要 】

Blueberries are a rich source of polyphenols, which include anthocyanin bioactive compounds. Epidemiological evidence indicates that incorporating blueberries into the diet may lower the risk of developing type 2 diabetes (T2DM). These findings are supported by pre-clinical and clinical studies that have shown improvements in insulin resistance (i.e., increased insulin sensitivity) after obese and insulin-resistant rodents or humans consumed blueberries. Insulin resistance was assessed by homeostatic model assessment-estimated insulin resistance (HOMA-IR), insulin tolerance tests, and hyperinsulinemic-euglycemic clamps. Additionally, the improvements in glucose tolerance after blueberry consumption were assessed by glucose tolerance tests. However, firm conclusions regarding the anti-diabetic effect of blueberries cannot be drawn due to the small number of existing clinical studies. Although the current evidence is promising, more long-term, randomized, and placebo-controlled trials are needed to establish the role of blueberries in preventing or delaying T2DM.

【 授权许可】

Unknown