Recent Advances in the Synthesis of Coumarin Derivatives from Different Starting Materials

Biomolecules

卷:10

Stela Jokić¹  Dajana Gašo-Sokač¹  Maja Molnar¹  Melita Lončarić¹ 

[1] Faculty of Food Faculty Osijek, Josip Juraj Strossmayer University, 31000 Osijek, Croatia;

关键词: synthesis;    coumarins;    knoevenagel condensation;    pechmann reaction;   

DOI  :  10.3390/biom10010151

来源: DOAJ

【 摘 要 】

The study of coumarin dates back to 1820 when coumarin was first extracted from tonka bean by Vogel. Compounds containing coumarin backbone are a very important group of compounds due to their usage in pharmacy and medicine. Properties and biological activities of coumarin derivatives have a significant role in the development of new drugs. Therefore, many different methods and techniques are developed in order to synthesize coumarin derivatives. Coumarin derivatives could be obtained from different starting materials with various methods but with big differences in yield. This review summarized various methods, techniques and reaction conditions for synthesis of coumarins from different compounds such as aldehydes, phenols, ketones and carboxylic acids.

【 授权许可】

Unknown