Study of lung function test in association with laboratory findings of serum iron in patients with chronic obstructive pulmonary disease

Clinical Epidemiology and Global Health

卷:16

Piush Sharma¹  Gaurav Gupta²  Vasudeva Murthy Challakere Ramaswamy³  Ruchita Banseria⁴  Harish Chandra Barjatiya⁵  Vikram Palsaniya⁵  Sunil Kumar Gothwal⁵  Yogendra Singh⁶  Pramod Kumar Goyal⁶ 

[1] Corresponding author. Department of Community Medicine, JLN Medical College, Ajmer, India.;

[2] Department of Chemistry, Maharishi Arvind College of Pharmacy, Ambabari Circle, Ambabari, Jaipur, 302023, India;

[3] Department of Pharmacognosy, Maharishi Arvind College of Pharmacy, Ambabari Circle, Ambabari, Jaipur, 302023, India;

[4] Department of Community Medicine, JLN Medical College, Ajmer, India;

[5] Department of Medicine, JLN Medical College, Ajmer, India;

[6] Department of Pharmacology, Maharishi Arvind College of Pharmacy, Ambabari Circle, Ambabari, Jaipur, 302023, India;

关键词: COPD;    FVC;    FEV1;    Serum iron;   

DOI  :  

来源: DOAJ

【 摘 要 】

Background: The current cross-sectional study analyses patients' plasma iron measurements and spirometry to determine the relationship between serum iron, percent transferrin saturation, serum ferritin, total iron-binding capacity (TIBC), and forced expiratory flow (FEF 25–75%), forced expiratory volume 1(FEV1)/Forced vital capacity (FVC), FVC, and FEV1. Methods: Spirometry measurements were assessed by comparing reference values based on age, height, sex, and race. Descriptive analysis of data included percentages, means, and standard deviations. Multivariate analyses were done using the Pearson correlation test and the multiple linear regression method. Results: According to the findings, the average age of those who participated in the study was 59.63 ± 10.32 years old. Serum iron concentrations were shown to be extremely significant and positively correlated with the percent anticipated values of FVC, FEV1/FVC FEV1, and FEF (25–75%). The total iron-binding capacity was extremely significant and linked strongly with the percent expected values of FVC, FEV1, FEF (25–75%), and FEV1/FVC. The percent transferrin saturation was extremely significant and linked positively with the percent anticipated values of FVC, FEV1, FEF (25–75%), and FEV1/FVC. Conclusion: Plasma iron levels were independently linked with both FEV1 and FEF (25–75%) percent predicted in the current investigation. Consequently, the blood iron concentration in COPD patients can be utilized as a biomarker for assessing disease severity because it is relatively simple and inexpensive.

【 授权许可】

Unknown