Prognostic factors and outcomes of COVID-19 cases in Ethiopia: multi-center cohort study protocol

BMC Infectious Diseases

卷:21

Tewodros Haile¹  Workeabeba Abebe¹  Haftom Taame²  Getachew Demoz³  Natinael Brehau³  Mihretab Salasibew⁴  Susan J. Whiting⁵  Menbeu Sultan⁶  Miraf Walelegn⁶  Woldesenbet Waganew⁶  Dereje Duguma⁶  Aschalew Worku⁶  Akilili Azazh⁶  Sisay Teklu⁶  Yakob Seman⁶  Berhane Redae⁶  Muluwork Tefera⁶  Sisay Yifru⁶  Rahel Argaw⁶  Masresha Tessema⁷  Yaregal Fufa⁷  Getachew Tollera⁷  Misker Amare⁷  Atkure Defar⁷  Muhammed Ahmed⁷  Asefa Deressa⁷  Geremew Tasew⁷  Ebba Abate⁷  Frehiwot Teka⁷  Saro Abdella⁷  Dereje Nigussie⁷  Eshetu Ejeta⁷  Eyasu Tigabu⁷  Feyisa Regasa⁷  Tsinuel Nigatu⁸  Getnet Mitike⁹  Frehiwot Nigatu⁹  Eskinder Wolka⁹  Tegbar Yigzaw¹⁰  Alemayehu Argaw¹¹  Tefera Belachew¹¹  Dawit Wolday¹²  Amare Deribew¹³  Tola Tolesa¹⁴  Wondwossen Amogne¹⁴  Million Molla¹⁵  Arnaud Laillou¹⁶ 

[1] Addis Ababa University;

[2] Africa CDC;

[3] COVID-19 Isolation and Treatment Center, Eka Kotebe General Hospital;

[4] Children’s Investment Fund Foundation;

[5] College of Pharmacy and Nutrition, University of Saskatchewan;

[6] Ethiopian Ministry of Health;

[7] Ethiopian Public Health Institute;

[8] Harvard T.H. Chan School of Public Health;

[9] International Institute for Primary Health Care;

[10] Jhpiego-Innovating;

[11] Jimma University;

[12] Mekelle University;

[13] Nutrition International;

[14] Saint Paul’s Hospital;

[15] Saint Peter Hospital;

[16] UNICEF;

关键词: COVID-19;    Prognostic Factors;    Outcomes of COVID;    Cohort;    Ethiopia;   

DOI  :  10.1186/s12879-021-06652-0

来源: DOAJ

【 摘 要 】

Abstract Background The coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus (SARS-CoV-2) and became pandemic after emerging in Wuhan, China, in December 2019. Several studies have been conducted to understand the key features of COVID-19 and its public health impact. However, the prognostic factors of COVID-19 are not well studied in the African setting. In this study, we aim to determine the epidemiological and clinical features of COVID-19 cases, immunological and virological courses, interaction with nutritional status, and response to treatment for COVID-19 patients in Ethiopia. Methods A multi-center cohort study design will be performed. Patients with confirmed COVID-19 infection admitted to selected treatment centers will be enrolled irrespective of their symptoms and followed-up for 12 months. Baseline epidemiological, clinical, laboratory and imaging data will be collected from treatment records, interviews, physical measurements, and biological samples. Follow-up data collection involves treatment and prognostic outcomes to be measured using different biomarkers and clinical parameters. Data collection will be done electronically using the Open Data Kit (ODK) software package and then exported to STATA/SPSS for analysis. Both descriptive and multivariable analyses will be performed to assess the independent determinants of the treatment outcome and prognosis to generate relevant information for informed prevention and case management. The primary outcomes of this study are death/survival and viral shedding. Secondary outcomes include epidemiological characteristics, clinical features, genetic frequency shifts (genotypic variations), and nutritional status. Discussion This is the first large prospective cohort study of patients in hospitals with COVID-19 in Ethiopia. The results will enable us to better understand the epidemiology of SARS-CoV-2 in Africa. This study will also provide useful information for effective public health measures and future pandemic preparedness and in response to outbreaks. It will also support policymakers in managing the epidemic based on scientific evidence. Trial Registration: The Protocol prospectively registered in ClinicalTrials.gov (NCT04584424) on 30 October, 2020.

【 授权许可】

Unknown