Synergistic Interaction and Binding Efficiency of Tetracaine Hydrochloride (Anesthetic Drug) with Anionic Surfactants in the Presence of NaCl Solution Using Surface Tension and UV–Visible Spectroscopic Methods

Gels

卷:8

Abdullah M. Asiri¹  Naved Azum¹  Anish Khan¹  Malik Abdul Rub¹  Maha M. Alotaibi² 

[1] Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah 21589, Saudi Arabia;

[2] Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia;

关键词: tetracaine hydrochloride;    sodium dodecyl sulfate;    sodium lauroyl sarcosine;    drug–surfactant mixed micelle;    synergistic interaction;   

DOI  :  10.3390/gels8040234

来源: DOAJ

【 摘 要 】

Surfactants are ubiquitous materials that are used in diverse formulations of various products. For instance, they improve the formulation of gel by improving its wetting and rheological properties. Here, we describe the effects of anionic surfactants on an anesthetic drug, tetracaine hydrochloride (TCH), in NaCl solution with tensiometry and UV–visible techniques. Various micellar, interfacial, and thermodynamic parameters were estimated. The outputs were examined by using different theoretical models to attain a profound knowledge of drug–surfactant mixtures. The presence of attractive interactions among drug and surfactant monomers (synergism) in mixed micelle was inferred. However, it was found that sodium dodecyl sulfate (SDS) showed greater interactions with the drug in comparison to sodium lauryl sarcosine (SLS). The binding of the drug with surfactants was monitored with a spectroscopic technique (UV–visible spectra). The results of this study could help optimize the compositions of these mixed aggregates and find the synergism between monomers of different used amphiphiles.

【 授权许可】

Unknown