Immunological Prognostic Factors in Multiple Myeloma

International Journal of Molecular Sciences

卷:22

Ewelina Grywalska¹  Jacek Roliński¹  Marcin Pasiarski²  Iwona Smarz-Widelska³  Barbara Sosnowska-Pasiarska⁴  Stanisław Góźdź⁵  Dominika Bębnowska⁶  Paulina Niedźwiedzka-Rystwej⁶  Rafał Hrynkiewicz⁶ 

[1] Department of Clinical Immunology and Immunotherapy, Medical University of Lublin, 20-093 Lublin, Poland;

[2] Department of Immunology, Faculty of Health Sciences, Jan Kochanowski University, 25-317 Kielce, Poland;

[3] Department of Nephrology, Cardinal Stefan Wyszynski Provincial Hospital in Lublin, 20-718 Lublin, Poland;

[4] Department of Oncocardiology, Holy Cross Cancer Centre, 25-734 Kielce, Poland;

[5] Faculty of Medicine and Health Sciences, The Jan Kochanowski University, 25-516 Kielce, Poland;

[6] Institute of Biology, University of Szczecin, 71-412 Szczecin, Poland;

关键词: cytokines;    immune cells;    markers;    multiple myeloma;    prognostic factors;   

DOI  :  10.3390/ijms22073587

来源: DOAJ

【 摘 要 】

Multiple myeloma (MM) is a plasma cell neoplasm characterized by an abnormal proliferation of clonal, terminally differentiated B lymphocytes. Current approaches for the treatment of MM focus on developing new diagnostic techniques; however, the search for prognostic markers is also crucial. This enables the classification of patients into risk groups and, thus, the selection of the most optimal treatment method. Particular attention should be paid to the possible use of immune factors, as the immune system plays a key role in the formation and course of MM. In this review, we focus on characterizing the components of the immune system that are of prognostic value in MM patients, in order to facilitate the development of new diagnostic and therapeutic directions.

【 授权许可】

Unknown