Frontiers in Pharmacology | 卷:11 |
Effects of Early and Delayed Antiretroviral Therapy on Plasma Anti-CD4 Autoreactive IgG and Its Association With CD4+ T-Cell Recovery in Acute HIV-Infected Individuals | |
Lifeng Liu1  Bin Su1  Hao Wu1  Wei Xia1  Tong Zhang1  Xiaofan Lu1  Aixin Song1  Rui Wang1  Zhen Li1  Zhuang Wan3  Wei Jiang4  Zhenwu Luo4  | |
[1] Beijing Key Laboratory for HIV/AIDS Research, Beijing, China; | |
[2] Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, China; | |
[3] Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, United States; | |
[4] Division of Infectious Diseases, Medical University of South Carolina, Charleston, SC, United States; | |
关键词: CD4+ T cells; acute HIV infection; antiretroviral therapy; autoantibody; men who had sex with men (MSM); | |
DOI : 10.3389/fphar.2020.00449 | |
来源: DOAJ |
【 摘 要 】
BackgroundPlasma levels of anti-CD4 autoantibodies are increased in chronically HIV-infected patients and inversely correlated with CD4+ T-cell recovery under viral-suppressive antiretroviral therapy (ART). However, it remains unknown the effect of early ART on plasma anti-CD4 autoantibody levels in acute HIV infection (AHI).MethodsIn this cohort study, we evaluated the effect of early and delayed initiation of ART on plasma anti-CD4 autoantibody levels in AHI individuals (n = 90). Blood samples were collected from men who had sex with men (MSM) with acute infection, pre-ART, and 4, 24, 48, and 96 weeks after ART. Plasma levels of anti-CD4 immunoglobulin G (IgG) were measured by ELISA.ResultsWe found that plasma anti-CD4 IgG levels were significantly increased in AHI individuals compared with healthy controls (HCs) prior to ART. Notably, early ART decreased plasma anti-CD4 IgG to the levels similar to HCs starting at 24 weeks (W). However, delayed initiation of ART did not significantly reduce plasma anti-CD4 IgG levels in AHI individuals. Moreover, the peripheral CD4+ T-cell counts were inversely correlated with plasma anti-CD4 IgG levels in AHI individuals at 48 and 96 W after early ART but not after delayed ART.ConclusionsTaken together, our findings demonstrate for the first time that early ART, but not delayed initiation of ART, is effective in influencing anti-CD4 autoantibody production and recovering CD4+ T-cell counts in AHI individuals.
【 授权许可】
Unknown