MicroRNAs Related to TACE Treatment Response: A Review of the Literature from a Radiological Point of View

Diagnostics

卷:12

Lory Saveria Crocè¹  Matteo Cesarotto¹  Cristina Marcello¹  Mauro Giuffrè¹  Maria Assunta Cova¹  Alessandro Marco Bozzato¹  Marco Francesco Maria Cavallaro²  Riccardo Pizzolato³  Paola Martingano³  Fabio Pozzi Mucelli³  Roberta Antea Pozzi Mucelli³  Devis Pascut⁴  Claudio Tiribelli⁴ 

[1] Department of Medical, Surgical and Health Sciences, University of Trieste, 34151 Trieste, Italy;

[2] Department of Radiology, ASUGI, Ospedale Maggiore, 34149 Trieste, Italy;

[3] Department of Radiology, ASUGI, Ospedale di Cattinara, 34149 Trieste, Italy;

[4] Liver Research Center, Fondazione Italiana Fegato—ONLUS, Basovizza, 34149 Trieste, Italy;

关键词: microRNA (miRNA);    biomarkers;    prognostic biomarkers;    liver;    liver cirrhosis;    liver tumor;   

DOI  :  10.3390/diagnostics12020374

来源: DOAJ

【 摘 要 】

Hepatocellular Carcinoma (HCC) is the sixth most common cancer in the world. Patients with intermediate stage (Barcelona Clinic Liver Cancer, B stage) hepatocellular carcinoma (HCC) have been able to benefit from TACE (transarterial chemoembolization) as a treatment option. MicroRNAs (miRNAs), i.e., a subclass of non-coding RNAs (ncRNAs), participate in post-transcriptional gene regulation processes and miRNA dysfunction has been associated with apoptosis resistance, cellular proliferation, tumor genesis, and progression. Only a few studies have investigated the role of miRNAs as biomarkers predicting TACE treatment response in HCC. Here, we review the studies’ characteristics from a radiological point of view, also correlating data with radiological images chosen from the cases of our institution.

【 授权许可】

Unknown