Review of Newly Identified Functions Associated With the Heat-Labile Toxin of Enterotoxigenic Escherichia coli

Frontiers in Cellular and Infection Microbiology

卷:9

Rahul Nandre²  Weiping Zhang³  Pengpeng Xia⁴  Guoqiang Zhu⁴  Qiangde Duan⁴ 

[1] College of Veterinary Medicine, Institute of Comparative Medicine, Yangzhou University, Yangzhou, China;

[2] Department of Microbiology and Immunology, Uniformed Services University, Bethesda, MD, United States;

[3] Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, IL, United States;

[4] Joint International Research Laboratory of Agriculture and Agri-Product Safety of Ministry of Education of China, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, China;

关键词: LT (heat-labile toxin);    ETEC;    enterotoxicity;    adherence;    adjuvanticity;   

DOI  :  10.3389/fcimb.2019.00292

来源: DOAJ

【 摘 要 】

Heat-labile toxin (LT) is a well-characterized powerful enterotoxin produced by enterotoxigenic Escherichia coli (ETEC). This toxin is known to contribute to diarrhea in young children in developing countries, international travelers, as well as many different species of young animals. Interestingly, it has also been revealed that LT is involved in other activities in addition to its role in enterotoxicity. Recent studies have indicated that LT toxin enhances enteric pathogen adherence and subsequent intestinal colonization. LT has also been shown to act as a powerful adjuvant capable of upregulating vaccine antigenicity; it also serves as a protein or antigenic peptide display platform for new vaccine development, and can be used as a naturally derived cell targeting and protein delivery tool. This review summarizes the epidemiology, secretion, delivery, and mechanisms of action of LT, while also highlighting new functions revealed by recent studies.

【 授权许可】

Unknown