Effects of cognitive training on resting-state functional connectivity of default mode, salience and central executive networks

Frontiers in Aging Neuroscience

卷:8

Chunbo eLi¹  Ting eLi²  Changyue eHou³  Dezhong eYao³  Cheng eLuo³  Weifang eCao³  Yan eCheng⁴  Lijuan eJiang⁴  Xinyi eCao⁴ 

[1] Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University;

[2] Changning Mental Health Center;

[3] Key Laboratory for NeuroInformation of Ministry of Education, Center for Information in BioMedicine, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, School of Life Science and Technology, University of Electronic Science and Technology of China;

[4] Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine;

关键词: Aging;    cognitive training;    functional connectivity;    brain network;    resting state fMRI;   

DOI  :  10.3389/fnagi.2016.00070

来源: DOAJ

【 摘 要 】

Neuroimaging studies have documented that ageing can disrupt certain higher cognitive systems such as the default mode network (DMN), the salience network (SN) and the central executive network (CEN). The effect of cognitive training on higher cognitive systems remains unclear. This study used a one-year longitudinal design to explore the cognitive training effect on three higher cognitive networks in healthy older adults. The community-living healthy older adults were divided into two groups: the multi-domain cognitive training group (24 sessions of cognitive training over a three-month period) and the wait-list control group. All subjects underwent cognitive measurements and resting-state functional magnetic resonance imaging (fMRI) scanning at baseline and at one year after the training ended. We examined training-related changes in functional connectivity (FC) within and between three networks. Compared with the baseline, we observed maintained or increased FC within all three networks after training. The scans after training also showed maintained anti-correlation of FC between the DMN and CEN compared to the baseline. These findings demonstrated that cognitive training maintained or improved the functional integration within networks and the coupling between the DMN and CEN in older adults. Our findings suggested that multi-domain cognitive training can mitigate the ageing-related dysfunction of higher cognitive networks.

【 授权许可】

Unknown