Estrogen Receptors-Mediated Apoptosis in Hormone-Dependent Cancers

International Journal of Molecular Sciences

卷:23

Rosa Sirianni¹  Vincenzo Pezzi¹  Adele Chimento¹  Ivan Casaburi¹  Arianna De Luca¹  Francesca De Amicis¹  Paola Avena¹ 

[1] Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via Pietro Bucci, Arcavacata di Rende, 87036 Cosenza, Italy;

关键词: estrogens;    estrogen receptors;    apoptosis;    intrinsic/extrinsic apoptotic pathways;    cancer cells;   

DOI  :  10.3390/ijms23031242

来源: DOAJ

【 摘 要 】

It is known that estrogen stimulates growth and inhibits apoptosis through estrogen receptor(ER)-mediated mechanisms in many cancer cell types. Interestingly, there is strong evidence that estrogens can also induce apoptosis, activating different ER isoforms in cancer cells. It has been observed that E2/ERα complex activates multiple pathways involved in both cell cycle progression and apoptotic cascade prevention, while E2/ERβ complex in many cases directs the cells to apoptosis. However, the exact mechanism of estrogen-induced tumor regression is not completely known. Nevertheless, ERs expression levels of specific splice variants and their cellular localization differentially affect outcome of estrogen-dependent tumors. The goal of this review is to provide a general overview of current knowledge on ERs-mediated apoptosis that occurs in main hormone dependent-cancers. Understanding the molecular mechanisms underlying the induction of ER-mediated cell death will be useful for the development of specific ligands capable of triggering apoptosis to counteract estrogen-dependent tumor growth.

【 授权许可】

Unknown