Early prediction of response to cetuximab and radiotherapy by FDG-PET/CT for the treatment of a locoregionally advanced squamous cell carcinoma of the hypopharynx

Medicina

卷:50

Jean-François Daisne¹  Arvydas Burneckis²  Mindaugas Grybauskas²  Eduardas Aleknavičius³ 

[1] Department of Radiation Oncology, Clinique et Maternité Sainte-Elisabeth, Namur, Belgium;

[2] Department of Radiation Oncology, National Cancer Institute, Vilnius, Lithuania;

[3] Radiotherapy and Drug Therapy Centre, National Cancer Institute, Vilnius, Lithuania;

关键词: Cetuximab;    Head and neck cancer;    Predictive marker;    FDG-PET/CT;    Radiotherapy;   

DOI  :  10.1016/j.medici.2014.09.003

来源: DOAJ

【 摘 要 】

Cetuximab (CTX) is used for the concurrent treatment with radiotherapy (RT) in squamous cell carcinoma of head and neck (HNSCC). There are no reliable clinical predictive markers of effectiveness of CTX at yet. We describe the clinical case of patient who received a CTX/RT to cure locoregionally advanced hypopharyngeal SCC. 2-Deoxy-2-[18F]fluoro-d-glucose positron emission tomography and computed tomography (18FDG-PET/CT) was performed before the treatment and repeated 10 days after CTX induction dose. A repeated 18FDG-PET/CT scan showed dramatic decrease of metabolic parameters. Patient had a complete response after treatment and is still alive and cured after 5 years.

【 授权许可】

Unknown