Circular RNAs: emerging cancer biomarkers and targets

Journal of Experimental & Clinical Cancer Research

卷:36

Wenrong Xu¹  Yu Zhang¹  Wei Liang¹  Xu Zhang¹  Hui Qian¹  Jingyan Chen¹  Peng Zhang¹ 

[1] Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University;

关键词: CircRNA;    Cancer;    ceRNA;    Biomarker;    Target;   

DOI  :  10.1186/s13046-017-0624-z

来源: DOAJ

【 摘 要 】

Abstract CircRNAs are a class of RNA molecules that structurally form closed loops. CircRNAs are abundant in eukaryotic transcripts and show certain levels of tissue and cell specificity. CircRNAs have been suggested to regulate gene expression at transcriptional, post-transcriptional, and translational levels. An increasing number of studies have shown that circRNAs play important roles in the development and progression of diseases including cancer. In particular, circRNAs have shown great potential in cancer diagnosis, prognosis, and therapy. In this review, we provide an overview of the biogenesis and characteristics of circRNAs, succinctly describe their functions, and comprehensively discuss about the recent advances in the roles of circRNAs in cancer with an emphasis on their clinical values.

【 授权许可】

Unknown